Music is an important part of the cultural fabric of the region. A partial list of musical families, 2nd, 3rd and 4th Generations, from the Muscle Shoals region include:
| Angela & Zack Hacker |
| Ava & Eddie Aldridge |
| Barry, Matthew & Mark Beckett |
| Bill, Melissa, Ann, Will, Nick Foster |
| Bobby & Jordan Denton |
| Butler Twins |
| Charles Rose & Edna Carter |
| Chip & Cody Geiser |
| Christine Gentry & Ken Lovelace |
| David & Patterson Hood |
| Dexter, Jimmy, Jay, JJ (Jason) Johnson |
| Donna Godchaux & David Mackay |
| Donnie Fritts & Father Huey Fritts |
| Earl “Peanutt” Montgomery Family |
| Edd & Lloyd Jones |
| Freeman Family (Brass Bands) |
| Freeman Family (Singing Schools) |
| Gary & Shane Baker |
| Grown Folks Band |
| Harvey & Buddy Thompson |
| James & Dillon LeBlanc |
| James & Libby Counts |
| Jamie Barrier/Pine Hill Haints/Clarabelle & Creeps |
| Jimmy & Angie Nutt |
| Joey & Eli Flippen |
| John & David Briggs |
| John Paul White & Tony White |
| Marie Osmond’s son Stephen Craig recorded here |
| Max & Kirk Russell |
| Nancy & Scooter Muse/ Chris Tompkins |
| Pete & Don Carr |
| Ray Brothers |
| Rick, Rodney & Mark Hall |
| Sam, Jerry, Judd, Knox Phillips |
| Secret Sisters (Laura & Lydia) & Ricky Rogers |
| Spooner Oldham & Mark Naramore |
| Terry Richardson & family |
| Tony Fago & Celia Donohue |
| Tonya & Kelvin Holly |
| Tonya Holley & Jennie Strickland |
| Tori & Bob Carl Bailey |
| Travis & Monkey Wammack |
| Walt & Hannah Aldridge |
| Will & Jamie McFarlane |
| Zion Rock Godchaux & Kinsman Mackay |
